Discovery of 36 genes could open the way to new treatments for OCD and tic disorders

Researchers have identified 36 genes linked to obsessive-compulsive disorder and chronic tic disorders, a finding that could widen the search for new treatments.

Obsessive-compulsive disorder involves persistent intrusive thoughts and repetitive behaviors. Chronic tic disorders, including Tourette syndrome, involve sudden repeated movements or vocal reactions that are difficult to control.

The study, recently published in Nature Neuroscience, analyzed DNA from nearly 4,000 people diagnosed with the disorders. Many of the newly identified genes appeared in both conditions, suggesting that they share multiple biological pathways in the brain.

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Previously, we knew of a few genes with a strong influence, so the pharmaceutical industry had few opportunities to develop drugs.

“Previously, we knew of a few genes with a strong influence, so the pharmaceutical industry had few opportunities to develop drugs,” said study co-author J. Tishfield, professor emeritus at Rutgers University. He said the research now offers more than 30 potential targets for treatment development.

“These genes do not act individually,” Tishfield said. “They act in networks, and we can now target entire networks, which will make it easier to develop new therapies.” Several genes had also been linked previously to autism and schizophrenia. The researchers said the results could help develop medicines that target the underlying systems of these disorders instead of only reducing their symptoms.

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These genes do not act individually. They act in networks, and we can now target entire networks, which will make it easier to develop new therapies.