3D-printed patch aims to improve skin cancer treatment

A novel dissolvable patch, developed by researchers at Queen's University Belfast, promises to revolutionize localized skin cancer treatment. This innovative device features tiny microneedles designed to penetrate the skin's outer layer without causing bleeding.

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Skin cancer is a major public health concern, and current treatments often require repeated topical applications, invasive procedures, or can cause unwanted side effects.

The patch is engineered to deliver two anti-cancer drugs, curcumin and 5-fluorouracil, directly to the site of the localized skin cancer. Researchers believe this targeted approach could significantly reduce the need for repeated topical applications or more invasive procedures like injections, ultimately making treatment less painful and more convenient for patients.

Professor Dimitrios A Lamprou, chair of Biofabrication and Advanced Manufacturing at Queen's, highlighted the limitations of current treatments, which often involve repeated applications, invasive procedures, or unwanted side effects. He noted that many patients experience fear and discomfort associated with needles and injections.

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Many people also experience fear, discomfort, or inconvenience when treatments involve needles and injections.

"Minimally invasive microneedle systems that dissolve after application could provide a more patient-friendly, simpler and less painful way to deliver cancer medicines," Professor Lamprou stated. He added that the dissolvable nature of the microneedles could also decrease the risk of needle-stick injuries and reduce medical sharps waste.

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Minimally invasive microneedle systems that dissolve after application could provide a more patient-friendly, simpler and less painful way to deliver cancer medicines.

The research team utilized a one-step 3D-printing method to create the specialized patch. This technique allowed them to incorporate both anti-cancer drugs directly into a printable resin before manufacturing the microneedle patch. This approach ensures better skin penetration, higher drug loading, and a controlled two-stage drug release. The researchers envision this technology paving the way for next-generation medicine delivery systems, including vaccines and other vital drugs.

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Because the microneedles dissolve after use, they may also help reduce the risk of needle-stick injuries and decrease medical sharps waste.