Testosterone-derived hormone DHT blamed for hair loss, enlarged prostates

Dihydrotestosterone (DHT), a derivative of testosterone, is the key culprit behind common male ailments like hair loss and enlarged prostates, according to an analysis in Dong-A Ilbo. While a fortunate few are genetically blessed, most men experience receding hairlines and urinary difficulties with age, both linked to DHT's actions.

DHT plays a crucial role throughout a man's life, from fetal development of reproductive organs to the growth of facial and body hair during puberty. In adulthood, it significantly influences prostate function. However, the hormone's activity continues as men age. In the prostate, DHT binds to androgen receptors, promoting cell growth that can lead to benign prostatic hyperplasia, constricting the urethra and impeding urine flow.

Paradoxically, the same hormone that promotes body hair growth actively attacks scalp hair. In hair follicles, DHT binds to androgen receptors, causing the hair growth cycle to shorten and the resting phase to lengthen. This results in hair that grows quickly only to fall out, eventually leading to miniaturized follicles and permanent hair loss. Medications like finasteride and dutasteride work by inhibiting the enzyme that converts testosterone to DHT, thus treating both conditions.

However, these treatments come with a significant caveat: they can cause sexual side effects, including decreased libido, erectile dysfunction, and reduced ejaculate volume, potentially leading to depression and anxiety. This presents men with a difficult choice between preserving their hair and maintaining their sexual function. The article also touches upon female hair loss, often linked to hormonal changes like menopause and postpartum shifts, and the impact of nutritional deficiencies and hair treatments.