Omani Researcher Advances Drug Discovery Through Innovative Molecular Synthesis

Dr. Anwaar Said Al Maqbali, an Assistant Professor at Sultan Qaboos University, has achieved a significant breakthrough in molecular synthesis, developing innovative methods with promising applications for future drug development. Her research, recognized with a win at the 12th National Research Award in the Culture, Social and Basic Sciences field under the Young Researcher category, centers on designing and analyzing a new class of biologically active molecules.

The study, titled “Stereoselective Asymmetric Syntheses of Molecules with a 4,5-Dihydro-1H-[1,2,4]-Triazoline Core Possessing an Acetylated Carbohydrate Appendage: Crystal Structure, Spectroscopy, and Pharmacology,” successfully synthesized a new series of chiral triazoline compounds. Dr. Al Maqbali utilized a precise chemical process known as 1,3-dipolar cycloaddition, incorporating carbohydrate-based components to enhance the molecules' biological relevance. Advanced analytical techniques, including high-resolution mass spectrometry, nuclear magnetic resonance (NMR), and single-crystal X-ray analysis, were employed to confirm the molecular structures and properties.

Pharmacological testing revealed significant potential for these synthesized compounds. Several derivatives demonstrated strong biological activity against 60 cancer cell lines, with notable effectiveness against leukemia cells. Additionally, promising anti-fungal and anti-bacterial properties were observed, suggesting the compounds could serve as versatile therapeutic agents. The research findings establish a reliable method for producing triazoline-based compounds for potential drug development.

Dr. Al Maqbali recommends further research, including broader biological evaluations, detailed structure–activity relationship studies, and investigations into the role of stereochemistry in enhancing drug effectiveness. The research team, which included several collaborators, has published their findings in the journal Molecules. Dr. Al Maqbali expressed that winning the National Research Award validates her efforts and motivates her to continue contributing impactful scientific work.

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Winning the National Research Award is a prestigious recognition that validates my research efforts and motivates me to continue contributing impactful, high-quality scientific work.